• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文OA文献 >Glutathione transferases in rat hepatoma cells. Effects of ascites cells on the isoenzyme pattern in liver and induction of glutathione transferases in the tumour cells.
【2h】

Glutathione transferases in rat hepatoma cells. Effects of ascites cells on the isoenzyme pattern in liver and induction of glutathione transferases in the tumour cells.

机译：大鼠肝癌细胞中的谷胱甘肽转移酶。腹水细胞对肝脏同工酶模式的影响以及肿瘤细胞中谷胱甘肽转移酶的诱导。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Rat hepatoma cells grown intraperitoneally as an ascites tumour were analysed with respect to their contents of cytosolic glutathione transferases. In contrast with normal liver tissue, the hepatoma cells were dominated by the class Pi glutathione transferase 7-7. All the major hepatic enzyme forms were down-regulated to almost undetectable concentrations. Livers of rats bearing ascites-hepatoma cells expressed low, but significant, amounts of protein which, by electrophoretic and immunochemical properties, appeared identical with transferase 7-7. This enzyme is not detectable in normal hepatocytes. Treatment of rats with trans-stilbene oxide induced the expression of transferase 7-7 in the livers of normal rats as well as in hepatoma-cell-bearing animals. In addition, a 2-fold induction of transferase 7-7 was measured in the hepatoma ascites cells. No significant elevation of any other enzyme forms in the hepatoma cells was noted.
机译：腹膜内生长为腹水肿瘤的大鼠肝癌细胞被分析其胞质谷胱甘肽转移酶的含量。与正常肝组织相反，肝癌细胞由Pi型谷胱甘肽转移酶7-7占主导。所有主要的肝酶形式均下调至几乎不可检测的浓度。带有腹水-肝癌细胞的大鼠肝脏表达的蛋白质含量低，但意义重大，通过电泳和免疫化学性质，这些蛋白质的含量与转移酶7-7相同。在正常肝细胞中无法检测到该酶。用二氧化二苯乙烯处理的大鼠诱导正常大鼠的肝脏以及荷肝细胞的动物中转移酶7-7的表达。另外，在肝癌腹水细胞中测量了转移酶7-7的2倍诱导。没有观察到肝癌细胞中任何其他酶形式的显着升高。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号